TARDBP and amyotrophic lateral sclerosis: Similarly, increased DNA damage was seen in the frontal cortex sections from patients with FTLD-TDP-43, the spinal cord of ALS patients carrying the TDP43 Q331K mutation, as well as in fibroblasts derived from a TDP-43 ALS patient with M337V mutation (Guerrero et al., 2019; Konopka et al., 2020; Wu et al., 2020).