NR2F1 and Bosch-Boonstra-Schaaf optic atrophy syndrome: Interestingly, some BBSOAS patients show specific neocortical malformations, such as macrocephaly and ventricular enlargement/asymmetry (Chen et al., 2016; Kaiwar et al., 2017), suggesting that impairments in the basic mechanism of NP self-renewal and neurogenesis could be associated with NR2F1 haploinsufficiency.