By exploring the effect of acupuncture on rats with hypoxic-ischemic brain injury, it is found that acupuncture may reduce the degree of neuronal injury after ischemia by inhibiting apoptosis and increasing the expression of glial cell derived neurotrophie factor (GDNF) and brain-derived neurotrophic factor (BDNF), further promote the growth and development, and improve the function of ethology (Zhang et al., 2015). Here, GDNF is linked to ischemia.