In metastatic breast cancer patients, plasma Tie-1 levels were statistically significantly decreased as compared with pre-operation after 6 weeks of chemotherapy [10], and a recent in vitro study indicated that the overexpression of Tie-1 in multiple ovarian cancer cell lines decreased cisplatin sensitivity indicating that this may be a key gene inducing platinum resistance [17]. The gene discussed is TIE1; the disease is ovarian carcinoma.