In contrast to severe influenza, COVID-19 patients exhibited a hyperinflammatory profile in their peripheral blood mononuclear cells, with a particular upregulation of TNF/IL-1β-driven inflammatory responses, and type I IFN responses coexist with TNF/IL-1β-driven inflammation in monocytes from severe COVID-19 patients 42. The gene discussed is IL1B; the disease is COVID-19.