In the series studies published by Xu x et al34, 35, a ubiquitin-related gene named USP22 was proved as a glycolysis inducer by deubiquitinating and stabilizing HIF1α, which promoted hypoxia-induced HCC stemness; moreover, they constructed lipopolyplex nanoplatforms to deliver both USP22 shRNA and sorafenib, effectively inhibiting the development of HCC in vitro and in vivo. Here, HIF1A is linked to hepatocellular carcinoma.