CLCF1 and cancer: For example, Song M and his colleagues 39 reported a crosstalk signaling based on chemokine in HCC; they discovered that cancer-associated fibroblasts (CAFs) derived CLCF1 could increase the secretion of CXCL6 and TGF-β1 in tumor cells, enhancing cancer stemness; CXCL6 and TGF-β1, in turn, activated ERK 1/2 signaling of CAFs to create more CLCF1, forming a positive feedback loop to promote HCC progression.