GO and KEGG enrichment analysis revealed that these 100 mRNAsi phenotype-based DEGs were mainly enriched in pathways related to TME, such as extracellular matrix structural constituent, cell junction assembly, regulation of angiogenesis, mesenchymal cell differentiation, ECM receptor interaction and focal adhesion; some classical cancer pathways were emerged as well, like PI3K-AKT signaling and WNT signaling pathways (Figure 3C). Here, AKT1 is linked to cancer.