Wei Y et al. 40 discovered that IL-17A expressed and secreted by lymphatic endothelial cells in the TME could preferentially interact with CD133+ HCC cells in vitro, leading to the self-renewal and tumorigenesis by hepatoma stem cells; besides, CD133+ CSCs could, in turn, activate cytokine IL-17A expression in lymphatic endothelial cells. The gene discussed is PROM1; the disease is hepatocellular carcinoma.