These results validated that in the NPC microenvironment, LBH upregulation in NPC cells leads to augmented exosomal distribution of LBH protein, and that cellular internalization of LBH+ exosomes increases LBH levels in NPC cells, which downregulates VEGFA expression by modulating CRYAB phosphorylation. The gene discussed is VEGFA; the disease is nasopharyngeal carcinoma.