LBH protein in NPC cells can be transferred into HUVECs and themselves via paracrine and autocrine signaling mediated by exosomes; elevated LBH levels in recipient cells inhibit CRYAB-dependent VEGFA expression and secretion, which might be mediated by protein-protein interactions; downregulated VEGFA-VEGFR signaling alleviates EMT progression and angiogenesis in NPC. The gene discussed is LBH; the disease is nasopharyngeal carcinoma.