Moreover, VEGFA downregulation led to less extracellular VEGFA secretion from both NPC cells and HUVECs treated with LBH+ exosomes, resulting in decreased VEGFA levels in the interstitium of NPC tissues and weakened phosphorylation of VEGFR, which is in accordance with the mitigated EMT progression and angiogenesis we observed. The gene discussed is KDR; the disease is nasopharyngeal carcinoma.