We searched and examined point mutations and InDels within the amino acid coding sequences, CNAs, and CNDs of the TP53 and PTEN genes, and PIK3CA(H1047R & E545K) and AKT1(E17K) activating mutations in the METABRIC and TCGA human breast cancer datasets (MB-TCGA) from 3326 tumors 22, 23, 66, 72, 73. This evidence concerns the gene PTEN and breast carcinoma.