Previous studies also showed that conditional knockout of both Pten and Tp53 in MGECs of MMTV-Cre; PtenF/F; Tp53F/F female mice and WAP-Cre; PtenF/F; Tp53F/F female mice resulted in tumor development in 9 and 11 months, respectively, which were faster than their single gene deletion counterparts, suggesting a synergistic role of double Pten and P53 deficiencies in breast tumorigenesis 77. This evidence concerns the gene TP53 and neoplasm.