To clarify the relationship between DNASE1L3 activity and glucose metabolism in HCC, PET/CT (fluoro-2-D-deoxyglucose F18 ([18F]-FDG) imaging and the serum DNASE1L3 activity of 41 patients with HCC were used to assess the role of DNASE1L3 in glucose metabolism. Here, DNASE1L3 is linked to hepatocellular carcinoma.