Virus in hepatitis B-related HCC patients are more likely to occurring A1762T/G1764A Cp mutants, which influences the expression of both the pre-core/core and the pregenomic (pg) RNA transcripts and lead to Cp-mutant might not be recognized by E2F4 and explain why low expression of HBV in TT. The gene discussed is E2F4; the disease is hepatocellular carcinoma.