In the case of breast cancer (BrCa), the affected transcripts include Breast Cancer 1 suppressor and Epidermal Growth Factor Receptor 2 (HER2) 1, along with Transglutaminase type 2 (TG2) 2, which is reported to be present at higher levels in cancer and in surrounding stroma 3 and is involved in cancer survival, spheroid production 4, resistance to chemotherapy, emergence of stem cells and epithelial-mesenchymal transition (EMT) 5-7. The gene discussed is BRCA1; the disease is cancer.