ERBB2 and neoplasm: To verify any association between upregulation of TGM2 and aggressive phenotype, we extended the investigation to consider gene expression profiles extracted from the GSE16732 dataset of 40 cell lines 29,30 (including the 16 ER+, 8 ER-/HER2+ and 16 ER-/PR-/HER2- cell lines as defined in Material and Methods section) characterized by a different expression of diagnostic markers routinely employed in histological typing of the tumour.