As predicted, after pretreatment with the combination of caspase-8 and caspase-9 inhibitors (z-IETD-fmk + z-LEHD-fmk) in HCT116 and DLD-1 cells, these two caspases were inhibited and none of the treatments (HF, ATS and HF-ATS) induced apoptosis (Figure S3 and S4). Here, CASP8 is linked to hydrops fetalis.