This is in agreement with the fact that NgR1 and NgR3 can interact with many receptors inducing various signaling pathways for B-cell activation, which is of great significance in MS since its histopathological hallmark indicates the presence of autoreactive B-cells in follicles within the meninges and can lead to progressive neurodegeneration 77. The gene discussed is RTN4RL1; the disease is myeloid sarcoma.