Models that may resemble these patterns of immune cell-associated lesion profiles can be observed in the Theiler's Murine Encephalomyelitis Virus (TMEV) where the chronic progressive disease course is associated with potentiated myelin reactive CD4+ and CD8+ T cells 26 or the adoptive transfer of CD8+ autoreactive T cells from humanized mice that target PLP to produce profound brain inflammation 27. This evidence concerns the gene CD8A and brain inflammatory disease.