High concentrations of BAFF have been observed in patients with various autoimmune diseases, such as RA, SLE, Sjogren's syndrome, systemic sclerosis, as well as in patients with myelin oligodendrocyte glycoprotein antibody (MOG-Ab) associated demyelination (a separate disease from MS and aquaporin-4 IgG-positive NMO) 8, 29. The gene discussed is TNFSF13B; the disease is autoimmune disease.