High concentrations of BAFF have been observed in patients with various autoimmune diseases, such as RA, SLE, Sjogren's syndrome, systemic sclerosis, as well as in patients with myelin oligodendrocyte glycoprotein antibody (MOG-Ab) associated demyelination (a separate disease from MS and aquaporin-4 IgG-positive NMO) 8, 29. This evidence concerns the gene MOG and autoimmune disease.