Toll-like receptor 4 (TLR4) is widely distributed in CNS, expressed in astrocytes, microglia, vascular smooth muscle cells and endothelial cells, and it is an important pattern recognition receptor (PRR) on nerve cell membranes 7.On exposure to conditions such as ischemia, TLR4 expression is upregulated, which amplifies the neuroinflammation cascade via multiple signaling pathways 8-13. This evidence concerns the gene TLR4 and ischemia.