Intriguingly, we observed that the mRNA expression of MMP9 was not obviously changed following G6PD overexpression or knockdown in ccRCC cell lines, which seemed to be inconsistent with the results of TCGA dataset mining which indicated both genes were highly expressed and positively correlated at the mRNA level in ccRCC tumor specimens and normal control. This evidence concerns the gene MMP9 and nonpapillary renal cell carcinoma.