CCNE1 and neoplasm: Furthermore, univariate Cox regression analysis revealed that high expression levels of G6PD, Cyclin E1 and MMP9, age at surgery, pathologic T stage, M stage, Fuhrman tumor grade, tumor laterality, as well as TNM stage were significant predictors of poor overall survival in ccRCC patients, whereas gender and N stage failed to be prognostic factors (Table 2).