Other genes with known roles in adult synaptic function implicated in schizophrenia by the SCHEMA exome sequencing analysis (17) are GRIA3, encoding the AMPA receptor subunit 3 (75), and CACNA1G, encoding the Cav3.1 channel (76,77), while such genes prioritized by fine-mapping schizophrenia-associated loci in the recent PGC3 GWAS (16) include GRM1 (78), GABBR2 (79), CLCN3 (80), and CACNA1C (81). This evidence concerns the gene GRM1 and schizophrenia.