A previous study reported that a nutritional formulation consisting of lysine, proline, arginine, ascorbic acid and epigallocatechin gallate can inhibit PCa invasion by altering MMP expression [38], which indicates that PSMA may regulate the expression of MMP7 and MMP9 by altering the biosynthesis of arginine and proline. This evidence concerns the gene MMP9 and posterior cortical atrophy.