ANGPTL2 and diabetes mellitus: However, excessive expression of ANGPTL2 can cause chronic inflammatory response and irreversible tissue remodeling, leading to the occurrence of related diseases including obesity metabolic diseases, type 2 diabetes mellitus, atherosclerosis [15], tumors [19,20] and autoimmune diseases [21], etc. In ANGPTL2 knockout mouse, apoptosis of vascular endothelial senescent cells and promotion of endothelial repair can slow down the progression of atherogenesis [22].