Myo1b is also overexpressed in Esophageal Squamous Cell Carcinoma (ESCC) clinical samples, in this cancer Myo1b is associated with cancer cell aggressiveness and metastasis, downstream genes controlled by Myo1b includes MMP1/13 both of which are highly expressed in ESCC clinical specimens [71]. Here, MMP1 is linked to esophageal squamous cell carcinoma.