As we hypothesized earlier (Figure 2), our proposal is that B lymphocytes overexpressing myo1g are intrinsically more apt to migrate and that this ability together with increased cell contacts with the vessels allow the cells to migrate more efficiently to tissues where normally they are not supposed to migrate, producing in this way more infiltrates to the CNS and testis, which are strong indicators of severity of the disease in Leukemia. The gene discussed is MYO1G; the disease is leukemia.