et al reported that Myo1b is overexpressed in colon cancer patients, here Myo1b increased the migration and invasion of colon cancer cells both in vitro and in vivo through a mechanism that included activation of RhoA and cytoskeletal remodeling [74], those results suggest that Myo1b could be a useful biomarker of high potential of metastasis and poor prognosis in colon cancer and potentially could be used as a therapeutic target for colorectal cancer metastasis. The gene discussed is RHOA; the disease is colonic neoplasm.