Further detection of SMAD5 in keloid fibroblasts revealed a 1.3-fold or 1.2-fold increase in SMAD5 protein levels in pcDNA-H19 or miR-196b-5p inhibitor groups and a 70% or 30% decrease in SMAD5 protein levels in H19-siRNA or miR-196b-5p mimic groups (Figure 5(c)). This evidence concerns the gene SMAD5 and keloid.