The candidate genes list contained many fat marker genes (such as LPL, peroxisome proliferator activated receptor gamma (PPARγ), FABP4), and a large number of adipogenic differentiation studies have been carried out on them, many of the other genes might be involved in the regulation of adipocyte differentiation and obesity. The gene discussed is LPL; the disease is obesity due to melanocortin 4 receptor deficiency.