Abcg1, Aldoa, Mrap, Pex13, Aldh6a1, Egln3, G0s2 and Syn2 are significantly increased in adipose or liver tissue of ob/ob mice compared with lean mice, suggesting these genes are associated with obesity, are very rarely reported to be related to adipogenesis. The gene discussed is G0S2; the disease is obesity due to melanocortin 4 receptor deficiency.