Although a previous study indicated that THEMIS2 might act as a tumor suppressor and reduced THEMIS2 level exhibited relative resistance to apoptotic drugs such as tamoxifen and staurosporine in MCF-7 breast cancer cells [42], our data revealed the opposite results to demonstrate that THEMIS2 exerted the oncogenic function to promote cell proliferation and sphere formation in TNBC cells (Supplementary Fig. 3). Here, THEMIS2 is linked to breast carcinoma.