LKB1 is important in regulating glucose and lipid metabolism in various metabolic tissues, including hepatic LKB1-suppressed gluconeogenesis and inhibition of amino acid catabolism.2, 3 Previous research has shown that adipocyte-specific deletion of LKB1 promotes brown adipose tissue mass and consequently prevents high-fat diet (HFD)-induced obesity.4 This evidence concerns the gene STK11 and obesity due to melanocortin 4 receptor deficiency.