TRIB2-OE cells also showed increased number and size of colonies (Fig. 3B) and increased capability to invade through Matrigel in Boyden chambers (Fig. 3C), suggesting that TRIB2 may play a major role as a driver to promote aggressive behavior which is frequently observed in antiandrogenic therapy-resistant prostate cancer cells. The gene discussed is TRIB2; the disease is Familial prostate cancer.