Notably, we found a strong upregulation of the neuronal transcription factor, BRN2, and the stemness transcription factor, SOX2, in TRIB2-OE enzalutamide-resistant cells (Figs. 4, A and B and S8), which were characterized to promote lineage plasticity in prostate cancer cells (16, 19). This evidence concerns the gene TRIB2 and prostate cancer.