To address this, we transfected LNCaP and PCa-2B cells with full-length human TRIB2 gene and found that the TRIB2-overexpressing (TRIB2-OE) cells (LNCaP-TRIB2 and PCa-2B-TRIB2) show increased levels of prosurvival proteins, p-Akt and Bcl-xL, and decreased level of Forkhead Box O3, a tumor suppressor (Fig. 3A). Here, FOXO3 is linked to neoplasm.