RALA and Familial prostate cancer: Forskolin treatment of the prostate cancer cell line PC-3 led to internalisation of AQP3, whereas overexpression of E-cadherin or knockdown of the Ras superfamily small GTPase RalA led to translocation of AQP3 to the plasma membrane [70], although whether the effect of forskolin was via RalA or direct PKA phosphorylation of either AQP3 itself or proteins involved in its trafficking is not clear.