Forskolin treatment of the prostate cancer cell line PC-3 led to internalisation of AQP3, whereas overexpression of E-cadherin or knockdown of the Ras superfamily small GTPase RalA led to translocation of AQP3 to the plasma membrane [70], although whether the effect of forskolin was via RalA or direct PKA phosphorylation of either AQP3 itself or proteins involved in its trafficking is not clear. Here, AQP3 is linked to prostate carcinoma.