In addition to their reports in aHUS, other complement variants have also been observed in additional thrombotic phenotypes [36] including recurrent pregnancy loss (C3 c.2203C > T) [37], HELLP syndrome (CD46 c.1058C > T, CD46 c.38C > T) [38, 39], and drug-induced thrombotic microangiopathy (CFH c.2850G > T, CFH c.3148A > T) [28]. Here, C3 is linked to thrombotic microangiopathy.