The highest number of hypomethylated/up-regulated genes after PEG-AuNPs exposure (BCL2L1, LAMA1, RUNX1, PTGS2, CCND1, ARHGEF1, ETS1, NFKB2, SGK1, COL9A2, G6PC3, COL7A1, CD44, COL9A2, ICAM5, BSG, SHB, NRP2) has functional classification in cancer-related pathways, e.g., PI3K-Akt signaling or VEGFA-VEGFR2, extracellular matrix organization, or others. Here, ARHGEF1 is linked to cancer.