Likewise, the highest number of deregulated genes (MAPKAP1, FGF3, AKT2, NRG2, FGFR2 IGF2, PTBP1, CCND1, WNT7B) after the Fe3O4NPs exposure was identified in cancer-related pathways, among them PI3K/AKT signaling, signaling by receptor tyrosine kinases or PIP3 activated AKT signaling. This evidence concerns the gene IGF2 and cancer.