Various cancer-related genes (BCL2L1, RASGRP2, TRAF2, BCL2L11, CCND1, TFG, NOTCH3, AKT1, PAX8, AKT1, PARP3, SOX9, ANAPC1, SPTBN1) were deregulated also by SiO2NPs exposure. The gene discussed is PAX8; the disease is cancer.