Honokiol effectively downregulated the protein expression of HDAC3, EMT markers (Snail, Slug, and Twist), CEBP/β, and phosphorylated NF-κB-p65, but not HDAC1/2, phosphorylated NF-κB-p52 or p50, and markedly upregulated ER stress-related markers (phosphorylated elf2α and GADD153) in gastric cancer cells (Fig. 7A). This evidence concerns the gene TWIST1 and gastric cancer.