However, due to ACE2 is critically important in the cellular entry of SARS and SARS-CoV-2, it is possible that hypertensive COVID-19 patients treated with drugs that increase ACE2, e.g., ACE inhibitors and AT1R blockers, are at a higher risk for the development and severity SARS-CoV-2 infection [15]. This evidence concerns the gene ACE2 and COVID-19.