To assess whether high blood pressure and organ dysfunction contribute to the increased risk for SARS-CoV-2 infection, hACE2 transgenic mice were induced hypertensive by high salt feeding (1% NaCl) and subcutaneous infusion of angiotensin II (Ang II, 500 ng/mg/day), via osmotic minipumps, for 3 weeks before SARS-CoV-2 infection. This evidence concerns the gene AGT and hypertensive disorder.