A mechanism underlying the favorable response of HPV-related cancers to chemoradiotherapy is reported that chemoradiotherapy causes cell damage and inflammation, leading to the release of inflammatory cytokines such as IL-6, IL-8, and tumor necrosis factor (TNF)-α, as well as Damage-associated molecular patterns (DAMPs) such as High-mobility group-box 1 (HMGB1), and upregulation of signals that promote phagocytosis by dendritic cells such as calreticulin [26]. This evidence concerns the gene HMGB1 and cancer.