In vitro studies report agonists of the AHR, which interestingly was shown to induce a robust DNA demethylation of the Cyp1a1 promoter upon dioxin exposure [133], may induce up to a threefold increase in the ALS-linked TDP-43 protein in BE-M17 (human neuronal cell line), motor neuron differentiated iPSCs and the murine brain [134]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.