Although the IMpower130 trial (West et al. 2019) demonstrated that atezolizumab combined with carboplatin and nab-paclitaxel had a better OS benefit than carboplatin and nab-paclitaxel in front-line management of treatment-naïve, nonsquamous NSCLC in the wild-type population, the trial eliminated individuals with EGFR/ALK mutations and/or liver metastases and offer negligible survival benefit to these cases. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.