Although individuals with PD-L1-positive NSCLC have a greater OS benefit attributed to atezolizumab, PD-L1 expression alone seems to partially explicate the OS benefit in individuals with PD-L1-positive NSCLC receiving atezolizumab plus cytotoxic chemotherapy for front-line management (Chalabi et al. 2020; Mansfield et al. 2020). Here, CD274 is linked to non-small cell lung carcinoma.