Moreover, all the patients in our cohort have long standing RA (range 8–43 years), and the presence of autoreactive T cells in all samples suggests that the patients have either long-lived memory T cells or are continuously exposed to citrullinated Tenascin C. Having knowledge on which TCR genes or segments are overused in context of autoimmunity, can potentially be translated into targeting of these specific segments in order to re-introduce immune homeostasis. This evidence concerns the gene TNC and rheumatoid arthritis.