MBD2 and colorectal carcinoma: Next, to identify the effect of cell apoptosis induced by SP treatment, we focused on histone-lysine methyltransferases (HMTs) and demethylases (HDLs) because several types of HMTs and HDLs are overexpressed in CRC, and the knockdown of HMTs and HDLs suppresses CRC proliferation via CRC cell apoptosis [16, 17].