Using GENT analysis (http://gent2.appex.kr/gent2/), we found that the expression level of HECTD2 was not different between the control and CRC samples (Supplementary Fig. S7), implying that HECTD2 upregulation by propionate in CRC promotes EHMT2 proteasomal degradation by inducing polyubiquitination. This evidence concerns the gene HECTD2 and colorectal carcinoma.