The RNA-seq results revealed upregulation of TNFAIP1 after SP treatment and EHMT2 knockdown in CRC cell lines, and the induction of TNFAIP1 was confirmed by qRT-PCR analysis, implying that propionate-induced TNFAIP1 expression by downregulating EHMT2 (Fig. 5A). Here, EHMT2 is linked to colorectal carcinoma.