Interestingly, clusterin, the only tubular injury marker not increasing more among cases, has been found to be a sensitive marker of AKI induced by nephrotoxic medication such as calcineurin inhibitors in non-human primates.35 Pesticides proposed to have calcineurin inhibitory properties have been put forth as the cause of CKDnt,36 but considering that clusterin increase is not evident among cases, this seems unlikely to explain the IKI observed among the agricultural workers studied here. Here, CLU is linked to acute kidney injury.