During the COVID-19 pandemic, compared with the same period last year, we found that the proportion of patients from Shaanxi Province (81.77% vs 62.33%), smoking (44.62% vs 34.25%), alcoholism (14.62% vs 5.48%), arteriography (60.77 vs 40.41), EuroSCORE [6.5 (2–9) vs. 2 (0–5)] score, emergency admission (50.00% vs 21.23%), severe patients (54.62$% vs 27.40%), leucocyte count [6.59 (4.95–9.62) vs 6.14 (4.86–8.08)]109/L and Pro-BNP [857.50 (241.00–2222.50) vs 542.40 (113.45–1776.75)] ng/L were increased (P < 0.05). The gene discussed is NPPB; the disease is alcohol dependence.