Future work looking at the effects of these biologic TNF-α inhibitors in mouse models that combine both amyloid and tau pathology, along with the use of CSF1R inhibitors to deplete microglia, will allow us to elucidate the role of microglia-derived TNF-α in the protective effects of these biologic TNF-α inhibitors on both amyloid and tau pathology. Here, MAPT is linked to amyloidosis.