Confirming the observations made above, infection with all three L. major induces (cluster 1) neutrophil recruitment, myeloid activation, and production of cytokines/chemokines (e.g. Trem1, Trem3, C5ar1, Ltf, Ptgs2, Ccl2, Ccl12, Ccl17, etc.). This evidence concerns the gene PTGS2 and infection.