The cytokines IL-6, IL1-ß, and TNF-α were the highest in the L. majorWT group and surprisingly not recapitulated in the L. majorR group; IL-6 in C57BL/6 mice was reported to be responsible for Th2 responses but not required to control the disease since IL-6 KO mice were able to control infection [43]. The gene discussed is TNF; the disease is infection.