In the receiver operating characteristic curve (ROC) about the predictability for prostate cancer, the area under the curve (AUC) for miR-221 in EVs from plasma was 0.98 (95% CI: 0.94 to 1.02, p < 0.0001), while AUC for PSA was 0.86 (95% CI: 0.73 to 0.98, p < 0.01) (Fig 5B). The gene discussed is KLK3; the disease is Familial prostate cancer.