Lastly, studies assessing efficacy of intervention strategies aimed at mitigating cardiometabolic complications in CPHIV may benefit by monitoring these mitokines, as suggested in a study of adults living with HIV infection that determined associations of FGF21 expression with the beneficial “beiging” of adipose tissues and better energy homeostasis in response to lifestyle modification [32]. This evidence concerns the gene FGF21 and HIV infectious disease.