Heparanases are endoglycosidases cleaving the heparan sulfate (HS), which leads to the remodelling of the extracelullar matrix [64], and is connected to tumor metastasis, angiogenesis and inflammation, but Hpa2 does not exhibit this HS-degrading activity and is not a subject of proteolytic processing [65]. Here, HPSE is linked to neoplasm.