One variant (rs1043215) in the 3’ untranslated region and another downstream variant (rs143167654) of REST (also known as NRSF) showed surprisingly high ORs for migraine in the interaction analyses [total sample OR: 6.596 (95% CI: 1.90–22.86), Manchester OR: 5.769 (95%: 1.07–31.04), Budapest OR: 10.5 (95% CI: 1.37–80.38) for both SNPs]. This evidence concerns the gene REST and migraine disorder.