NR1H4 and atherosclerosis: As shown in Fig 5C, several pathways were enriched among all three models, such as LXR/RXR activation, atherosclerosis signaling, FXR/RXR activation, acute phase response signaling, IL-12 signaling and production in macrophages, production of nitric oxide and reactive oxygen species in macrophages, and LPS/IL-1 mediated inhibition of RXR function.