The reduction of tumor hypoxia in E7 RNA-LPX/LRT-treated mice was furthermore was associated with markedly increased proliferation of CD8+ tumor infiltrated lymphocytes (TIL) five days after LRT (Fig. 3e), as shown by the higher incorporation of the base analog BrdU in CD8+ TIL but not in CD4+ TIL. Here, CD4 is linked to neoplasm.