Reflecting the previous in vivo observation, co-culture with E7-specific CD8+T cells strongly increased the expression of MHC class I and PD-L1 on tumor cells (Supplementary Fig. 3b, c), likely a feedback mechanism in response to IFNγ secretion [32], whereas expression levels remained the same whether tumor cells were irradiated or not. The gene discussed is IFNG; the disease is neoplasm.