CD4 and neoplasm: Furthermore, E7 RNA-LPX vaccinated mice displayed a higher fraction of intratumoral CD4+, CD8+, NK cells (Fig. 2c) and E7-specific CD8+T cells in the tumor as well as in spleens and lymph nodes of treated mice (Fig. 2d) when compared to LRT with control RNA-LPX, which only mildly modulated these cell populations.