CD8A and neoplasm: In addition to radiation-induced reduction of tumor cell count and increase of tumor cell killing as compared to control RNA-LPX and E7 RNA-LPX alone (Fig. 3a, b), we characterized radiation-mediated effects on the local tumor microenvironment (TME) that could impact intratumoral E7-specific CD8+T cells induced by the E7 RNA-LPX vaccine (Fig. 2d).