With the data presented here, we add to the repertoire of possible mechanisms of combined cancer vaccination and LRT, which may deviate in dependence on multiple factors such as tumor innate immune infiltration, innate immune sensing, pre-existing adaptive immune responses, tumor-mutational burden, CD4+ or CD8+T cell reactive neoantigens, radiosensitivity and tumor immune suppression. This evidence concerns the gene CD8A and neoplasm.