We previously found that BM structure is an important microenvironment supporting the fate and functional polarity of EpSCs.[30] We observed that the proteins (type IV collagen, laminins, HSPG2, NID1, etc.)of BM structure and hemidesmosome complex (ITGA6) were severely damaged in the COVID‐19 skin tissues (Figure 4a). This evidence concerns the gene HSPG2 and COVID-19.