HGF and cancer: Konstorum and Lowengrub used a PDE‐based, multispecies model of the tumor microenvironment to simulate the interaction of HGF‐secreting cancer‐associated fibroblasts with c‐Met receptors on tumor cells, predicting that disrupting the HGF/c‐Met signaling with anti‐HGF or anti‐c‐Met therapy reduces tumor invasiveness and growth (Konstorum & Lowengrub, 2018).