CD22 and leukemia: The potential mechanisms that could explain the increase in LSM following hepatic injury IO would be differently related (i) to the secondary damage to the targeting of liver sinusoidal cells expressing the antigen expressed on malignant leukemia cells (CD22) and (ii) to the possible presence of cells malignancies within the hepatic vessels with consequent release of toxins and finally hepatic exposure to the cytotoxic metabolite (N‐Ac‐γ‐calicheamicin dimethyl hydrazine).5