MSC-secreted angiopoietin-1 (Ang-1) and keratinocyte growth factor (KGF) enhance restoration of disrupted alveolar–capillary barrier, while specific regulatory mRNAs in EVs mediate the protective effects of MSCs in pre-clinical models of bacterial or non-infectious acute lung injuries [95, 96]. The gene discussed is FGF7; the disease is acute lung injury.