ADAMTS5 is responsible for aggrecan degradation which may play important role in cartilage destruction of mouse osteoarthritis model [19]LAMA4, in the other hand, contributes to clustering of human osteoarthritic chondrocytes which is a part of morphology in OA [20, 21] Using IPA, it showed the protein interaction network of ADAMTS 5, LAMA4 and co-expression gene (Figure 4). Here, ACAN is linked to osteoarthritis.