IL1R1 and breast carcinoma: Additionally, rs949963 polymorphism of interleukin 1 receptor, type 1 (IL1R1) gene was associated with lower perceived attentional function in breast cancer patients (N = 397; OR = 1.98; 95% CI: 1.18, 3.30; p = 0.009), suggesting that cytokine dysregulation may negatively impact some cognitive domains (Merriman et al., 2014).