The association between APOE-E4 allelic variant and CRCI was firstly demonstrated by Ahles et al. (Ahles et al., 2003) in long-term survivors of breast cancer (N = 51, age = 55.9 ± 8.8) and lymphoma (N = 29, age = 55.8 ± 11.6) treated with standard-dose chemotherapy. This evidence concerns the gene APOE and breast carcinoma.