HMOX1 and Hepatic fibrosis: In a rat liver fibrosis model, the upregulation of HO-1 induced by magnesium isoglycyrrhizinate promoted the accumulation of iron and lipid peroxide, resulting in the ferroptosis of HSCs, while the antifibrotic effect of magnesium isoglycyrrhizinate was eliminated when ferrostatin-1 was used or HO-1 was silenced (Sui et al., 2018).