In a previous study, the ferroptosis inducer RSL3 aggravated hepatic steatosis and inflammation in methionine/choline-deficient (MCD) diet-induced NASH mice, while the treatment with a GPX4 activator, sodium selenite, relieved the RSL3-induced lipid peroxidation and cell death, thereby reducing the severity of NASH (Qi et al., 2020). Here, GPX4 is linked to metabolic dysfunction-associated steatohepatitis.