ACSL4 and hepatocellular carcinoma: In addition, the expression of long-chain acyl CoA synthase long chain family member 3 (ACSL3) and ACSL4 was dramatically elevated in hepatoma cells, and ACSL4 was involved in erastin-induced ferroptosis via 5-hydroxyeicosatetraenoic acid-mediated lipotoxicity (Ndiaye et al., 2020).